Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo
Abstract
Vitiligo is a depigmentation disorder that develops as a result of the progressive disappearance of epidermal melanocytes. The elevated level of amino acid metabolite homocysteine (Hcy) has been identified as circulating marker of oxidative stress and known as a risk factor for vitiligo. However, the mechanism underlying Hcy-regulated melanocytic destruction is currently unknown. The present study aims to elucidate the effect of Hcy on...
Paper Details
Title
Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo
Published Date
May 1, 2020
Journal
Volume
134
Issue
10
Pages
1127 - 1141
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