Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice
Abstract
The myeloproliferative neoplasms (MPN) polycythaemia vera, essential thrombocythaemia and primary myelofibrosis are chronic myeloid disorders associated most often with mutations in JAK2, MPL and CALR, and in some patients with additional acquired genomic lesions. Whilst the molecular mechanisms downstream of these mutations are now clearer, it is apparent that clinical phenotype in MPN is a product of complex interactions, acting between...
Paper Details
Title
Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice
Published Date
Jul 1, 2020
Journal
Volume
42
Pages
100708 - 100708
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