Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
Volume: 21, Issue: 4, Pages: 462 - 467
Published: Feb 22, 2021
Abstract
Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5'-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent anticancer agents like...
Paper Details
Title
Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
Published Date
Feb 22, 2021
Volume
21
Issue
4
Pages
462 - 467
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