Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system (SEDDS) by spray drying using Soluplus® as solid carrier

The objectives of the current work were (a) to investigate the suitability of soluplus®, a hydrophilic polymer, as a carrier for the entrapment of curcumin (CUR) SEDDS by the spray-drying process, and (b) to compare soluplus® with neusilin® US2, a hydrophobic high-capacity adsorbent for solid SEDDS. Both carriers produced free flowing powders with high CUR entrapment efficiency. When filled into capsules, approximately 95% of CUR was dissolved...