Trefoil factors share a lectin activity that defines their role in mucus

Volume: 11, Issue: 1
Published: May 13, 2020
Abstract
The mucosal epithelium secretes a host of protective disulfide-rich peptides, including the trefoil factors (TFFs). The TFFs increase the viscoelasticity of the mucosa and promote cell migration, though the molecular mechanisms underlying these functions have remained poorly defined. Here, we demonstrate that all TFFs are divalent lectins that recognise the GlcNAc-α-1,4-Gal disaccharide, which terminates some mucin-like O-glycans. Degradation of...
Paper Details
Title
Trefoil factors share a lectin activity that defines their role in mucus
Published Date
May 13, 2020
Volume
11
Issue
1
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