Reversal of Regioselectivity in Zinc‐Dependent Medium‐Chain Alcohol Dehydrogenase fromRhodococcus erythropolistoward Octanone Derivatives
Abstract
The zinc-dependent medium-chain alcohol dehydrogenase from Rhodococcus erythropolis (ReADH) is one of the most versatile biocatalysts for the stereoselective reduction of ketones to chiral alcohols. Despite its known broad substrate scope, ReADH only accepts carbonyl substrates with either a methyl or an ethyl group adjacent to the carbonyl moiety; this limits its use in the synthesis of the chiral alcohols that serve as a building blocks for...
Paper Details
Title
Reversal of Regioselectivity in Zinc‐Dependent Medium‐Chain Alcohol Dehydrogenase fromRhodococcus erythropolistoward Octanone Derivatives
Published Date
Jun 30, 2020
Journal
Volume
21
Issue
20
Pages
2957 - 2965
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