A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections
Abstract
Urinary tract infections (UTIs) typically evoke prompt and vigorous innate bladder immune responses, including extensive exfoliation of the epithelium. To explain the basis for the extraordinarily high recurrence rates of UTIs, we examined adaptive immune responses in mouse bladders. We found that, following each bladder infection, a highly T helper type 2 (TH2)-skewed immune response directed at bladder re-epithelialization is observed, with...
Paper Details
Title
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections
Published Date
May 18, 2020
Journal
Volume
21
Issue
6
Pages
671 - 683
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