Direct oral anticoagulant adsorption: Impact on lupus anticoagulant testing—Review of the literature and evaluation on spiked and patient samples

Background Direct oral anticoagulants (DOACs) interfere with lupus anticoagulant (LAC) testing. DOAC-Stop (D-S) represents a preanalytical strategy to cope with this issue. Objectives To assess D-S’s ability to remove DOACs from plasma and overcome DOAC interference in LAC assays and to evaluate D-S’s applicability in a representative patient cohort with routine LAC request. Methods Apixaban (30-933 ng/mL), edoxaban (31-1060 ng/mL), rivaroxaban...