Impact of neoadjuvant therapy on post‐operative pancreatic fistula: a systematic review and meta‐analysis

Introduction The use of neoadjuvant therapy (NAT) for pancreatic cancer is increasing, although its impact on post‐operative pancreatic fistula (POPF) is variably reported. This systematic review and meta‐analysis aimed to assess the impact of NAT on POPF. Methods A systematic literature search until October 2019 identified studies reporting POPF following NAT (radiotherapy, chemotherapy or chemoradiotherapy) versus upfront resection. The...