Epigenetics in non-classical monocytes support their pro-inflammatory gene expression

Volume: 225, Issue: 3, Pages: 151958 - 151958
Published: May 1, 2020
Abstract
• The majority of miRNAs specific to non-classical monocytes is related to signaling. • TRIM8 is targeted by two miRNAs, which are down-regulated in non-classical monocytes. • Non-classical monocytes have two hypo-methylated CpG sites upstream of the TRIM8 coding region. • LPS stimulated non-classical monocytes show high TNF expression along with high TRIM8 and low miRNA-20aand miRNA-106b. Non-classical human monocytes are characterized by...
Paper Details
Title
Epigenetics in non-classical monocytes support their pro-inflammatory gene expression
Published Date
May 1, 2020
Volume
225
Issue
3
Pages
151958 - 151958
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