Cytosolic Events in the Biogenesis of Mitochondrial Proteins

Mitochondrial proteins synthetized in the cytosol can be targeted to mitochondria at different stages of gene expression: as mRNAs, ribosome-nascent chain complexes, or complete precursor proteins.While almost all proteins use the same entry gate to the mitochondria, before and after it they can embark on different targeting and import pathways.Delays in mitochondrial protein import or mistargeting to other organelles affect cellular...