Non‐inasive vagus nerve stimulation—Hope or hype?

The vagus nerve is the tenth and longest of the cranial nerves, whose course runs from the brainstem to the splenic flexure. It is the main neural substrate of the parasympathetic nervous system and has both afferent and efferent pathways, although the former predominate (80%). An increasing body of evidence has demonstrated it has a central role in modulating gastrointestinal pain, inflammation, and motility. Within this issue of the Journal,...