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BrisSynBio Art-Science Dossier

Published on Apr 1, 2020in Nanoethics1.359
· DOI :10.1007/S11569-020-00368-2
Maria Fannin , Katy Connor + 1 AuthorsDarian Meacham3
Estimated H-index: 3
(UM: Maastricht University)
Abstract
Finding avenues for collaboration and engagement between the arts and the sciences (natural and social) was a central theme of investigation for the Responsible Research and Innovation (RRI) and Public Engagement programme at BrisSynBio, a BBSRC/EPSRC Synthetic Biology Research Centre that is now part of the Bristol BioDesign Institute at University of Bristol (UK). The reflections and experiments that appear in this dossier are a sample of these investigations and are contributed by Maria Fannin, Katy Connor and David Roden. Darian Meacham coordinated and introduces the dossier.
  • References (18)
  • Citations (0)
References18
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#1Michael Reinsborough (University of the West of England)H-Index: 1
Here I examine the potential for art-science collaborations to be the basis for deliberative discussions on research agendas and direction. Responsible Research and Innovation (RRI) has become a science policy goal in synthetic biology and several other high-profile areas of scientific research. While art-science collaborations offer the potential to engage both publics and scientists and thus possess the potential to facilitate the desired "mutual responsiveness" (Rene von Schomberg) between re...
1 CitationsSource
#1Massimiliano Simons (Katholieke Universiteit Leuven)H-Index: 2
A recurrent theme in the characterization of synthetic biology is the role of engineering. This theme is widespread in the accounts of scholars studying this field and the biologists working in it, in those of the biologists themselves, as well as in policy documents. The aim of this article is to open this black-box of engineering that is supposed to influence and change contemporary life sciences. Too often, both synthetic biologists and their critics assume a very narrow understanding of what...
1 CitationsSource
#1Jeanne AquiliH-Index: 1
Sheila Jasanoff, chercheure et professeure d’etudes en science et technologie a l’universite d’Harvard, publie son ouvrage Can science make sense of life? dans un contexte de grande inquietude internationale vis-a-vis des enjeux ethiques que posent les avancees de la recherche scientifique et ses applications concretes. On pense notamment a la forte mediatisation de la recente invention par la communaute scientifique d’une technologie pouvant modifier le genome vivant. Cette technologie d’edi...
2 Citations
#1Joseph Hawksworth (UoB: University of Bristol)H-Index: 2
#2Timothy J. Satchwell (UoB: University of Bristol)H-Index: 15
Last. Ashley M. Toye (UoB: University of Bristol)H-Index: 25
view all 14 authors...
Abstract Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle‐cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR‐mediated genome editing of an immortalised human erythroblast cell line (BEL‐A) to generate multiple enucleation competent cell lines deficient in individual blood groups. Edits are combined to generate a s...
10 CitationsSource
#2Rebecca E. Griffiths (National Health Service)H-Index: 8
Last. Jan FrayneH-Index: 23
view all 13 authors...
The generation of a sustainable supply of erythroid progenitors is essential for the reliable production of an in vitro derived red blood cell clinical product. Here the authors immortalize early human erythroblasts to generate the first cell line capable of differentiation into functional adult reticulocytes.
48 CitationsSource
#1Rachel HaleH-Index: 7
#2Julie KentH-Index: 1
1 Citations
#1Hallam StevensH-Index: 8
3 Citations
#2Hugo M. Macedo (Imperial College London)H-Index: 6
Last. Ashley M. ToyeH-Index: 25
view all 6 authors...
We describe a 3D erythroid culture system that utilises a porous polyurethane (PU) scaffold to mimic the compartmentalisation found in the bone marrow. PU scaffolds seeded with peripheral blood CD34+ cells exhibit a remarkable reproducibility of egress, with an increased output when directly compared to human bone scaffolds over 28 days. Immunofluorescence demonstrated the persistence of CD34+ cells within the scaffolds for the entirety of the culture. To characterise scaffold outputs, we design...
5 CitationsSource
#1Harriet Hawkins (RHUL: Royal Holloway, University of London)H-Index: 16
#2Elizabeth R. Straughan (Glas.: University of Glasgow)H-Index: 8
This paper offers an auto-ethnographic account of Midas, an immersive bio-media installation created by artist Paul Thomas. The experiences of the installation provide a stepping-off point for a discussion of the corporeal geographies and the nano-imaginaries that the work develops. Understanding the senses as a principle means whereby the body mingles with the world and with itself, we begin from a focus on Midas’s presentation of the inter-relations of touch, vision and hearing, thereby extend...
20 CitationsSource
#1Rachel Colls (Durham University)H-Index: 14
#2Maria Fannin (UoB: University of Bristol)H-Index: 7
Within geographical research on ‘the body’, a focus on the surfaces of bodies has been useful for considering how body boundaries, most often implied to begin and end at the skin, (de)limit, (de)regulate, and (de)stabilise what we come to know as ‘a body’. Such work draws attention to how meaning is inscribed ‘upon’ such surfaces and on the fluids that move across, within, and through those surfaces: for example blood, breast milk, and excrement. This paper, however, considers the potential for ...
28 CitationsSource
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