The Bulk Osteosarcoma and Osteosarcoma Stem Cell Activity of a Necroptosis‐Inducing Nickel(II)–Phenanthroline Complex
Abstract
We report the anti‐osteosarcoma and anti‐osteosarcoma stem cell (OSC) properties of a nickel(II) complex, 1 . Complex 1 displays similar potency towards bulk osteosarcoma cells and OSCs, in the micromolar range. Notably, 1 displays similar or better OSC potency than the clinically approved platinum(II) anticancer drugs cisplatin and carboplatin in two‐ and three‐dimensional osteosarcoma cell cultures. Mechanistic studies revealed that 1 induces...
Paper Details
Title
The Bulk Osteosarcoma and Osteosarcoma Stem Cell Activity of a Necroptosis‐Inducing Nickel(II)–Phenanthroline Complex
Published Date
Jun 22, 2020
Journal
Volume
21
Issue
19
Pages
2854 - 2860
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