Tracing Self-Reactive B Cells in Normal Mice
Abstract
BCR transgenic mice dominate studies of B cell tolerance; consequently, tolerance in normal mice expressing diverse sets of autoreactive B cells is poorly characterized. We have used single B cell cultures to trace self-reactivity in BCR repertoires across the first and second tolerance checkpoints and in tolerized B cell compartments of normal mice. This approach reveals affinity “setpoints” that define each checkpoint and a subset of...
Paper Details
Title
Tracing Self-Reactive B Cells in Normal Mice
Published Date
Jul 1, 2020
Journal
Volume
205
Issue
1
Pages
90 - 101
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History