Intracellular Delivery of Budesonide and Polydopamine Co‐Loaded in Endosomolytic Poly(butyl methacrylate‐ co ‐methacrylic acid) Grafted Acetalated Dextran for Macrophage Phenotype Switch from M1 to M2

In this study, a rationally designed nanocomposite (BUDPDA@MAP) composed of polydopamine (PDA) nanoparticle and anti‐inflammatory drug budesonide (BUD) encapsulated in a pH‐responsive endosomolytic polymer (poly(butyl methacrylate‐ co ‐methacrylic acid) grafted acetalated dextran, denoted by MAP), is proposed. The uniform nanocomposite is prepared using a microfluidic device. At low endosomal pH (5.5), MAP destabilizes the endosomal membranes...