Review paper
O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors
Abstract
Modifications of nuclear and cytoplasmic proteins with a single sugar, N ‐acetylglucosamine (GlcNAc), play roles in a wide variety of fundamental cellular processes, and aberrant O ‐GlcNAc profiles are associated with pathological progression of several chronic diseases. O ‐GlcNAc transferase (OGT) is the only enzyme to catalyze the attachment of GlcNAc to intracellular protein substrates. Considering its biological significance, selective and...
Paper Details
Title
O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors
Published Date
Jun 22, 2020
Journal
Volume
21
Issue
21
Pages
3026 - 3035
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