O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors

Modifications of nuclear and cytoplasmic proteins with a single sugar, N ‐acetylglucosamine (GlcNAc), play roles in a wide variety of fundamental cellular processes, and aberrant O ‐GlcNAc profiles are associated with pathological progression of several chronic diseases. O ‐GlcNAc transferase (OGT) is the only enzyme to catalyze the attachment of GlcNAc to intracellular protein substrates. Considering its biological significance, selective and...