The Use of Genetic Correlation and Mendelian Randomization Studies to Increase Our Understanding of Relationships between Complex Traits

Increasing access to large-scale genetic datasets in population-based studies allows for genetic association studies as a means to examine previously known and novel relationships among complex traits. In this review, we discuss two widely used approaches to leverage genetic data to study the links between traits: Genome-wide genetic correlation and Mendelian Randomization (MR) studies.Both genetic correlation and MR studies have provided...