Macrophage targeted amphotericin B nanodelivery systems against visceral leishmaniasis

Visceral leishmaniasis (VL), a potentially fatal systemic disease caused by the protozoan Leishmania donovani and Leishmania infantum, transmitted by phlebotomine sandflies. This VL is characterized by an uneven spell of fever, substantial weight loss, liver and spleen swelling, and anemia. The presently available therapies for VL are based on pentavalent antimony and amphotericin B (AmB) formulations. The failure of the first treatment is due...