The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains
Abstract
RNF12 is a widely expressed ubiquitin E3 ligase that is required for X-chromosome inactivation, regulation of LIM-domain containing transcription factors, and TGF-β signaling. A RING domain at the C terminus of RNF12 is important for its E3 ligase activity, and mutations in the RING domain are associated with X-linked intellectual disability. Here we have characterized ubiquitin transfer by RNF12, and show that the RING domain can bind to, and...
Paper Details
Title
The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains
Published Date
Jun 1, 2020
Journal
Volume
432
Issue
13
Pages
3790 - 3801
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