Gonadal dysfunction and beyond: Clinical challenges in children, adolescents, and adults with 47,XXYKlinefelter syndrome

Volume: 184, Issue: 2, Pages: 302 - 312
Published: May 16, 2020
Abstract
Klinefelter syndrome (KS) is the most frequent sex chromosomal aneuploidy. The karyotype 47,XXY originates from either paternal or maternal meiotic nondisjunction during gametogenesis. KS males are very likely to exhibit marked gonadal dysfunctions, presenting both in severely attenuated spermatogenesis as well as hypergonadotropic hypogonadism. In addition, neurocognitive and psychosocial impairments, as well as cardiovascular, metabolic and...
Paper Details
Title
Gonadal dysfunction and beyond: Clinical challenges in children, adolescents, and adults with 47,XXYKlinefelter syndrome
Published Date
May 16, 2020
Volume
184
Issue
2
Pages
302 - 312
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