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Modulation of immune crosstalk in COVID-19.

Published on May 14, 2020in Nature Reviews Immunology44.019
· DOI :10.1038/S41577-020-0342-1
Bérengère Salomé3
Estimated H-index: 3
(ISMMS: Icahn School of Medicine at Mount Sinai),
Bérengère Salomé2
Estimated H-index: 2
(ISMMS: Icahn School of Medicine at Mount Sinai)
+ -1 AuthorsZafar Mahmood7
Estimated H-index: 7
(ISMMS: Icahn School of Medicine at Mount Sinai)
Abstract
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#1Aaron J. Wilk (Stanford University)H-Index: 4
#1Aaron J. Wilk (Stanford University)H-Index: 2
Last. Taylor Hollis (Stanford University)H-Index: 2
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There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. Here, we apply single-cell RNA sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs) of 7 patients hospitalized with confirmed COVID-19 and 6 healthy controls. We identify substantial reconfiguration of peripheral immune cell phenotype in COVID-19, including a heterogeneous interferon-stimulated gene (ISG) signature, HLA class II downre...
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