Conformation, flexibility and hydration of hyaluronic acid by molecular dynamics simulations

Volume: 493, Pages: 108026 - 108026
Published: Jul 1, 2020
Abstract
Hyaluronic acid (HA) is a biopolymer of disaccharide with two alternate glycosidic bonds, β(1,3) and β(1,4). A molecular dynamics study presented here unveiled conformational variability in association with the flexibility of the glycosidic linkers, which depends on the number of disaccharide units. HA chain maintains a rigid rod-like conformation with short chain lengths. Crossover from a rod-like to a random−coil conformation is observed with...
Paper Details
Title
Conformation, flexibility and hydration of hyaluronic acid by molecular dynamics simulations
Published Date
Jul 1, 2020
Volume
493
Pages
108026 - 108026
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