shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination

Published: May 10, 2020
Abstract
Recombination is crucial for chromosome pairing and segregation during meiosis. SPATA22, along with its direct binding partner and functional collaborator, MEIOB, is essential for the proper repair of double-strand breaks (DSBs) during meiotic recombination. Here, we describe a novel point-mutated allele (shani) of mouse Spata22 that we isolated in a forward genetic screen. shani mutant mice phenocopy Spata22-null and Meiob-null mice: mutant...
Paper Details
Title
shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination
Published Date
May 10, 2020
Journal
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