Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

Volume: 16, Issue: 7, Pages: 783 - 790
Published: May 11, 2020
Abstract
Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane. Here, we contrast the structural and functional consequences of the binding of two natural product inhibitors of 5-LOX. The redox-type inhibitor nordihydroguaiaretic acid (NDGA) is...
Paper Details
Title
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Published Date
May 11, 2020
Volume
16
Issue
7
Pages
783 - 790
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