Functional heterogeneity in senescence
Abstract
Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokines from primary senescent cells. More recently, juxtacrine Notch signalling has been implicated in mediating secondary senescence...
Paper Details
Title
Functional heterogeneity in senescence
Published Date
May 5, 2020
Volume
48
Issue
3
Pages
765 - 773
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