The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors
Abstract
Autophagy is an intracellular lysosomal degradative pathway important for tumor surveillance. Autophagy deficiency can lead to tumorigenesis. Autophagy is also known to be important for the aggressive growth of tumors, yet the mechanism that sustains the growth of autophagy-deficient tumors is not unclear. We previously reported that progression of hepatic tumors developed in autophagy-deficient livers required high mobility group box 1 (HMGB1),...
Paper Details
Title
The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors
Published Date
May 7, 2020
Journal
Volume
11
Issue
5
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