Original paper
Chronic Treatment with Morphine Disrupts Acute Kinase-Dependent Desensitization of GPCRs
Abstract
Based on studies using mutations of the µ-opioid receptor (MOR), phosphorylation of multiple sites on the C-terminus has been recognized as a critical step underlying acute desensitization and the development of cellular tolerance. The aim of this study is to explore which kinases mediate desensitization of MOR in brain slices from drug-naïve and morphine-treated animals. Whole-cell recordings from locus coeruleus neurons were made, and...
Paper Details
Title
Chronic Treatment with Morphine Disrupts Acute Kinase-Dependent Desensitization of GPCRs
Published Date
May 3, 2020
Journal
Volume
98
Issue
4
Pages
497 - 507
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Notes
History