Translational regulation of Chk1 expression by eIF3a via interaction with the RNA-binding protein HuR
Abstract
eIF3a is a putative subunit of the eukaryotic translation initiation factor 3 complex. Accumulating evidence suggests that eIF3a may have a translational regulatory function by suppressing translation of a subset of mRNAs while accelerating that of other mRNAs. Albeit the suppression of mRNA translation may derive from eIF3a binding to the 5′-UTRs of target mRNAs, how eIF3a may accelerate mRNA translation remains unknown. In this study, we show...
Paper Details
Title
Translational regulation of Chk1 expression by eIF3a via interaction with the RNA-binding protein HuR
Published Date
May 29, 2020
Journal
Volume
477
Issue
10
Pages
1939 - 1950
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