Abstract A18: Characterization of K-RasG13D as a unique activating allele in a mouse model of colorectal cancer

The K-RAS (Kirsten rat sarcoma) oncoprotein is mutationally activated in ~40% of colorectal cancers (CRCs), and K-RAS mutation state is an excellent predictor of the failure of a cancer to respond to conventional chemotherapy or targeted therapy. The colonic epithelium provides a biologically interesting context in which to study the allele-specific characteristics of K-RAS, because CRC displays a broad spectrum of activating mutations that...