Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells

• The BCL2L12 gene transcription was characterized by functional analysis. • Novel active promoter of BCL2L12 gene was discovered in K562 cell line. • This study contributes to better understanding of BCL2L12 gene expression. The BCL2L12, one of the latest discovered members of the BCL2 family, has both pro- and anti-apoptotic roles that are cell-type-dependent. Its role in tumorigenesis is highly implicated. Sixty-three splice variants of this...