Altered Functional Brain Dynamics During Facial Affect Processing in Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 deletion syndrome (22qDS) is a neurodevelopmental disorder that leads to psychosis-spectrum symptoms in over 1/3 of affected individuals. Patients with 22qDS often exhibit global cognitive dysfunction with marked deficits in facial memory and social cognition. Neuroimaging in 22qDS has found an absence of face-selective activation in the fusiform gyrus and resting state abnormalities in large-scale brain networks. However,...