Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
Abstract
Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of diet-induced metabolic disease, including obesity and type 2 diabetes. Here we investigate whether heterozygous impairment of insulin receptor (IR) expression limited to peripheral, i.e. non-CNS, tissues of adult mice impacts the development of high-fat diet-induced metabolic deterioration. While exhibiting some features of insulin resistance,...
Paper Details
Title
Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
Published Date
Apr 29, 2020
Journal
Volume
11
Issue
1
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