Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy
Abstract
Arrhythmogenic cardiomyopathy (AC) is a genetic disease causing arrhythmia and sudden cardiac death with only symptomatic therapy available at present. Mutations of desmosomal proteins, including desmoglein-2 (Dsg2) and plakoglobin (Pg), are the major cause of AC and have been shown to lead to impaired gap junction function. Recent data indicated the involvement of anti-Dsg2 autoantibodies in AC pathogenesis. We applied a peptide to stabilize...
Paper Details
Title
Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy
Published Date
May 7, 2020
Journal
Volume
5
Issue
9
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