BCG-induced trained immunity: can it offer protection against COVID-19?

Published on May 11, 2020in Nature Reviews Immunology44.019
· DOI :10.1038/S41577-020-0337-Y
Luke A. J. O'Neill109
Estimated H-index: 109
(Trinity College, Dublin),
Mihai G. Netea1
Estimated H-index: 1
(University of Bonn)
Bacillus Calmette–Guerin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.
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