Emerging Insights into the Structure and Function of Complement C5a Receptors

The complement cascade is a critical part of our innate immune system that plays a crucial role in combating pathogenic infections. Complement C5a, a potent anaphylatoxin in the complement cascade, activates two different seven transmembrane receptors, namely C5aR1 and C5aR2. C5aR1 is a prototypical GPCR, while C5aR2, which exhibits functional analogy to ACKRs, does not exhibit any functional coupling to G proteins but engages βarrs upon...