GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity
Abstract
Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of patients with diabetes are not well understood. By using multiple mouse models of obesity and insulin resistance, we identify a common downregulation of IR with a reduction of mRNA expression of selenoproteins Txnrd3, Sephs2, and Gpx3 in...
Paper Details
Title
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity
Published Date
May 5, 2020
Journal
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