The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B 4 axis

Volume: 117, Issue: 21, Pages: 11674 - 11684
Published: May 11, 2020
Abstract
Significance Recent studies have implicated LTB 4 in inflammation in adipose tissue and in the subsequent development of insulin resistance. The mechanism by which LTB 4 is produced in adipose tissue has remained unknown, however. We now reveal that insulin regulates LTB 4 production in adipocytes via a PDK1–FoxO1–5-LO pathway and thereby maintains systemic insulin sensitivity. Whereas signaling pathways of insulin and LTB 4 have been...
Paper Details
Title
The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B 4 axis
Published Date
May 11, 2020
Volume
117
Issue
21
Pages
11674 - 11684
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