Acute stress induces visceral hypersensitivity via glucocorticoid receptor–mediated membrane insertion of TRPM8: Involvement of a non‐receptor tyrosine kinase Pyk2

Background Psychological stress is an important factor for the development and recurrence of irritable bowel syndrome (IBS). The mechanisms underlying stress‐induced visceral hypersensitivity (VH), a key pathophysiological component in IBS, are still incompletely understood. We aimed to test whether transient receptor potential melastatin 8 (TRPM8) participates in acute stress–induced VH. Methods Rats were subjected to 1‐hour water avoidance...