Photochromic meta-diamides for optical modulation of ligand activity and neuron function†
Volume: 19, Issue: 6, Pages: 854 - 857
Published: Jun 1, 2020
Abstract
Photopharmacology offers facile solutions for spatiotemporal control over ligand activity and receptor function. The meta-diamide insecticide acts on insect GABA receptors (GABARs) as an antagonist that causes firing of a neuron. We present here photochromic GABAR ligands azobenzene-meta-diamides (ABMDAs) by incorporating photoswitchable azobenzene with meta-diamides. ABMDAs showed good isomerization efficiency and fatigue resistance. Among...
Paper Details
Title
Photochromic meta-diamides for optical modulation of ligand activity and neuron function†
Published Date
Jun 1, 2020
Volume
19
Issue
6
Pages
854 - 857
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