A m⁶A Sensing Method by Its Impact on the Stability of RNA Double Helix

N 6 ‐Methyladenosine (m 6 A) is one of the most important RNA modifications in epigenetics. The development of detection method for m 6 A is limited by its abundance and structure. Although it has been previously reported that its presence has an impact on the complementary pairing of RNA, few assays have been developed using this finding. We used this discovery and designed a detection method based on Cas13a system, which has different...