Tokoronin Contained in Dioscorea tokoro Makino ex Miyabe Suppressed α‐MSH‐Induced Melanogenesis in B16 Cells via Suppression of Classical MAPK Pathway Activation

In this study, melanogenesis inhibition in B16 cells by eight compounds, namely, tokorogenin, tokoronin, yononin, gracillin, proto‐yonogenin, proto‐tokoronin, proto‐yononin, and proto‐gracillin, isolated from Dioscorea tokoro Makino ex Miyabe were evaluated. The results of the cytotoxicity and α ‐MSH‐induced melanogenesis inhibition effects of the eight compounds revealed that tokoronin was the most effective in terms of low‐cytotoxicity and...