Tumor specific methylome in Chinese high-grade serous ovarian cancer characterized by gene expression profile and tumor genotype
Abstract
ObjectiveExtensive genetic and limited epigenetics have been characterized by the Cancer Genome Atlas (TCGA) among Western High-grade serous ovarian cancer (HGSOC). The present study aimed to characterize Chinese HGSOC at genome scale.MethodsWe used reduced representation bisulfite sequencing to investigate whole-genome and tumor-specific DNA methylation in 21 HGSOC tumors paired with their normal tissues, followed by a replication study...
Paper Details
Title
Tumor specific methylome in Chinese high-grade serous ovarian cancer characterized by gene expression profile and tumor genotype
Published Date
Jul 1, 2020
Journal
Volume
158
Issue
1
Pages
178 - 187
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