Time Course of Evolving Ventilator-Induced Lung Injury: The “Shrinking Baby Lung”

Objectives: To examine the potentially modifiable drivers that injure and heal the “baby lung” of acute respiratory distress syndrome and describe a rational clinical approach to favor benefit. Data Sources: Published experimental studies and clinical papers that address varied aspects of ventilator-induced lung injury pathogenesis and its consequences. Study Selection: Published information relevant to the novel hypothesis of progressive lung...