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doi.org/10.1016/j.scr.2020.101803

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

..., Rasika A. Mathias
48
Stem Cell Research1.20
Volume: 46, Pages: 101803 - 101803
Published: Jul 1, 2020
Abstract
Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by copy number variations (CNVs). We observed that 149 hiPSC lines acquired 258 CNVs relative to donor DNA. We identified six recurrent regions of CNVs on chromosomes 1, 2, 3, 16 and 20 that overlapped with cancer...
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Paper Details
Title
Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program
DOI
doi.org/10.1016/j.scr.2020.101803
Published Date
Jul 1, 2020
Journal
Stem Cell Research
Volume
46
Pages
101803 - 101803
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