4E-T-bound mRNAs are stored in a silenced and deadenylated form

Volume: 34, Issue: 11-12, Pages: 847 - 860
Published: Apr 30, 2020
Abstract
Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms are still unclear. Here, we show that upon mRNA binding 4E-T represses translation and promotes deadenylation via the recruitment of the CCR4–NOT deadenylase complex. The interaction with CCR4–NOT is mediated...
Paper Details
Title
4E-T-bound mRNAs are stored in a silenced and deadenylated form
Published Date
Apr 30, 2020
Volume
34
Issue
11-12
Pages
847 - 860
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