Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins
Abstract
Solid tumor growth triggers a dynamic host response, which recapitulates wound healing and defines the tumor microenvironment (TME). In addition to the action of the tumor cells themselves, the TME is maintained by a myriad of immune and stromal cell-derived soluble mediators and extracellular matrix components whose combined action supports tumor progression. However, therapeutic targeting of the TME has proven challenging because of incomplete...
Paper Details
Title
Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins
Published Date
Aug 1, 2020
Journal
Volume
484
Pages
50 - 64
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Notes
History