APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers

Volume: 12, Issue: 5, Pages: 1171 - 1171
Published: May 6, 2020
Abstract
Background: WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here, we evaluate the mutational landscape of WNT signaling regulators in BRAF mutant cancers. Methods: we performed exome-sequencing on 24 BRAF mutant colorectal cancers and analyzed these data in combination with 175 publicly available BRAF mutant...
Paper Details
Title
APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers
Published Date
May 6, 2020
Journal
Volume
12
Issue
5
Pages
1171 - 1171
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