Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

Loss-in-weight feeders play a vital role in assuring blend and content uniformity as well as lot-to-lot powder traceability in continuous manufacturing. Irregular flow from the feeders propagates through the system, potentially resulting in out-of-specification product. Powder properties such as density, cohesion, and adhesion can cause large variability in the flow rate of ingredients from powder feeders. Feeding of active pharmaceutical...