Abstract IA27: Context-dependent role of KRAS in GI malignancies

Volume: 18
Published: May 1, 2020
Abstract
Oncogenic Kras (Kras*) plays a key role in tumor maintenance and therapeutic resistance in several cancer types, although the precise biologic functions and mechanisms are not completely understood. We had previously shown in pancreatic ductal adenocarcinoma that some tumors underwent spontaneous relapse and were devoid of Kras* expression and downstream canonical MAPK signaling, instead acquiring amplification and overexpression of the...
Paper Details
Title
Abstract IA27: Context-dependent role of KRAS in GI malignancies
Published Date
May 1, 2020
Volume
18
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